Fig. 12. Restoration of Hsp27 in cells containing G1961E ABCA4 (A) G1961E ABCA4 containing cells were transfected with Hsp27 and treated with VX-809. The data shows that increasing Hsp27 levels has no significant effect on its own. The combination of Hsp27 overexpression and addition of VX-809 are synergistic. (B) Hsp27 transfection, with or without VX-809 (20 µM). Protein density was normalized to Ezrin. Data were represented as mean ± SEM (n=3-6). One way Anova was used for statistics. *P<0.05; **P<0.01.